Multi-site investigation validates metabolic biomarkers for assessing RBC unit age

Research at Sinopia Biosciences analyzing metabolomics data previously revealed a three state, non-linear decay of red blood cells during storage. A new study published in the prestigious hematology journal, Blood, shows that with the measurement of just eight metabolites, the RBC storage age can be accurately predicted. Unlike previous studies, the investigation involved multiple sites, as well as different additive solutions, processing methods, and analytical setups for metabolite measurement. The success of the study is an independent confirmation of two separate laboratories and further validates the three state decay of red blood cells during blood bank storage. The work was completed by researchers from EURAC Research in Italy, the University of Colorado Denver, the University of Iceland, the Blood Bank at Landspitali-University Hospital, and Sinopia Biosciences.

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