Drug Side Effects
Sinopia Biosciences has developed a proprietary, state-of-the art systems biology and bioinformatics platform to study the safety of therapeutics at an unprecedented level of biochemical detail.
We are currently pursuing two areas in healthcare
Red blood cells and platelets are integral blood products for modern medicine with nearly 100 million units transfused per year. These cells undergo biochemical, physicochemical, and morphological changes during storage that may affect the quality and safety of transfusion. Sinopia’s platform has aided in better understanding the breakdown of these cells and we are pursuing novel media solutions to ameliorate these issues to improve safety and efficacy of transfusions.
Drug-induced Movement Disorders
Pharmaceuticals that affect neurotransmitter receptors, such as antipsychotics, antidepressants, and Parkinson’s medications, may cause side effects, such as movement disorders, at high rates. Using Sinopia’s platform, we have identified pathways that are implicated in causing these debilitating side effects. Sinopia is currently progressing repurposed therapeutics to combat movement disorders.
Paglia G, D'Alessandro A, Rolfsson O, Sigurjonsson OE, Bordbar A, Palsson S, Nemkov T, Hansen KC, Gudmundsson S, Palsson BO. "Biomarkers defining the metabolic age of red blood cells during storage" Blood Early View (2016).
Bordbar A, Johansson PI, Paglia G, Harrison SJ, Wichuk K, Magnusdottir M, Valgeirsdottir S, Gybel-Brask M, Ostrowski SR, Palsson S, Rolfsson O, Sigurjonsson OE, Hansen MB, Gudmundsson S, Palsson BO, "Identified metabolic signature for assessing red blood cell unit quality is associated with endothelial damage markers and clinical outcomes" Transfusion, 56(4):852 (2016).
Bordbar A, McCloskey DM, Zielinski DC, Sonnenschein N, Jamshidi N, Palsson BO, "Personalized whole-cell kinetic models of metabolism for discovery in genomics and pharmacodynamics" Cell Systems, 1:283 (2015).
Zielinski DC, Filipp F, Bordbar A, Smith J, Herrgard M, Mo ML, Palsson BO, "Pharmacogenomic and clinical data link non-pharmacokinetic metabolic dysregulation to drug side-effect pathogenesis" Nature Communications, 6:7101 (2015).
Paglia G, Sigurjonsson OE, Rolfsson O, Valgeirsdottir S, Hansen MB, Brynjolfsson S, Gudmundsson S, Palsson BO, "Metabolomic analysis of platelets during storage: a comparison between apheresis- and buffy coat-derived platelet concentrates" Transfusion, 55(2):301 (2015).
Paglia G, Sigurjonsson OE, Rolfsson O, Valgeirsdottir S, Hansen MB, Brynjolfsson S, Gudmundsson S, Palsson BO, “Comprehensive metabolomics study of platelets reveals the expression of discrete metabolic phenotypes during storage” Transfusion, 54(11): 2911 (2014).
Bordbar A, Monk JM, King ZA, Palsson BO, "Constraint-based models predict metabolic and associated cellular functions" Nature Reviews Genetics, 15(2):107 (2014).
Thomas A, Rahmanian S, Bordbar A, Palsson BO, Jamshidi N, “Network reconstruction of platelet metabolism identified metabolic signature for aspirin resistance” Scientific Reports, 4:3925 (2014).
Paglia G, Palsson BO, Sigurjonsson OE. “Systems biology of blood cells: Can it help to extend the expiration date?” Journal of Proteomics, 76:163-167 (2012).
Bordbar A, Jamshidi N, Palsson BO. "iAB-RBC-283: A proteomically derived knowledge-base of erythrocyte metabolism that can be used to simulate its physiological and patho-physiological states" BMC Systems Biology, 5:110 (2011).
Joshi A and Palsson BO. "Metabolic dynamics in the human red cell: Part I-A comprehensive kinetic model” Journal of Theoretical Biology, 152(2):285-286 (1989). (Parts II, III, IV)